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One molecule, called IP, moves into the fluid inside the cell and may ultimately bind to channels on internal calcium stores, causing Ca to be released into the cytoplasm

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"Oxidative stress" is defined the imbalance of oxidant/antioxidant forces in favor of the oxidant, During normal cellular metabolic processes free radicals and reactive metabolites are continuously generated, These oxidant products can injure and destroy the structures of cells or tissues

doi: 10.1084/jem.20060285 27 ZhouLLittmanDR

Yes, it is often used for relieving painful leg cramps and muscle spasms, especially those triggered by fatigue or fluid loss