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The article suggested a reason why so few cases had previously been found: If you do not look for something you will not diagnose it. McNeil dispatched a top official to meet with one of the studys authors

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Evidence provided through meta-analyses reported an odds ratio between 4.5 [95% confidence interval (CI), 2.67.7] and 6.1 (95% CI, 4.48.6) in C

However, under pathological conditions, disease-specific Syn variants may engage in promiscuous, nonfunctional interactions with a broad spectrum of cellular proteins, burdening the cellular quality control machinery and potentially triggering neuronal cell death if left unchecked