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Researchers at the University of Texas first characterized 5-amino-1MQ (5-amino-1-methyl quinolinium) in 2017 while searching for ways to inhibit nicotinamide-N-methyltransferase (NNMT) [1]

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2025;137(1):e70067

These benefits were accompanied by a significant reduction in the blood levels of homocysteine, a molecule with neurotoxic effects that is elevated in ALS patients and whose conversion into another molecule is dependent on methylcobalamin