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They are frequently investigated together because their potential mechanisms of action are thought to be complementary, creating a synergistic effect that is a popular subject of preclinical studies

Folate supplementation must not be started before B12 deficiency is treated, as this can precipitate or worsen neurological complications

Patients in our Doral clinic who complete both phases consistently report more visible skin texture changes than those who stop early

63 , 64 , 65 Nondrug interventions should be tried first

Hypokalemia and sudden death may occur in severe megaloblastic anemia which is treated intensely with vitamin B12