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In addition, low circulating concentrations of tryptophan have been observed in infectious and autoimmune diseases and also in disorders that involve cellular (Th1-type) immune activation [68]

165,206 Few studies have examined the role of vitamin B 6 on homocysteine-related disorders independently of folate and B 12 , but a meta-analysis with a total of 369,746 participants determined higher intake of B 6 was correlated with lower risk of coronary heart disease

And it could be placebo