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Pigmented dark circles stem from melanin accumulation in periorbital skin from chronic sun exposure without adequate protection, post-inflammatory hyperpigmentation from rubbing or allergies, genetic predisposition particularly in darker skin types, or hormonal influences affecting melanocyte activity

Free Radic Biol Med 20(3):463466

Hives, or raised itchy welts , can also appear

49.50 Tirzepatide is a dual GLP-1/GIP receptor agonist peptide that simultaneously activates both glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptors

2.5 Current Clinical Trials for Anti-Inflammatory Disease Modification in PD Current clinical trials on anti-inflammatory therapy in PD focus on the treatment of glucose metabolism, improvement of oxidative stress, and regulation of gut microbiota