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Patient age, sex, and inflammatory bowel disease phenotype associate with course of primary sclerosing cholangitis

In preclinical models, ERR activation: Stimulates expression of genes associated with aerobic exercise adaptation Enhances mitochondrial biogenesis and oxidative respiration Increases fatty acid oxidation in skeletal and cardiac muscle Supports endurance capacity and metabolic flexibility Because of these effects, the compound has been described in the literature as an exercise mimetic a molecule that may reproduce certain biochemical signatures of physical training without the training stimulus itself

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Lipotropics are nutrients involved in hepatic lipid handling and methyl-group transfer (for example, choline and methionine )

Most individuals experience little to no side effects