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Das S, Ciombor KK, and Haraldsdottir S, et al (2020) Immune-related adverse events and immune checkpoint inhibitor efficacy in patients with gastrointestinal cancer with Food and Drug Administration-approved indications for immunotherapy Oncologist 25 (8) 669679 PMID: 31943525 PMCID: 7418359 62

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Medical Treatments: Topical corticosteroids to reduce inflammation and itching Oral antihistamines to ease itching and help sleep Immune-modulating creams like tacrolimus or pimecrolimus for long-term control Antibiotics in case of infection from scratching Oral steroids in severe flare-ups (short-term use only) Lifestyle and Home Remedies: Moisturize regularly with thick creams or ointments Avoid contact with triggers (like nickel or strong detergents) Use mild, fragrance-free soaps Wear cotton gloves while doing housework Apply cold compresses to ease itching Maintain dry skin on your hands and feet to reduce excess moisture that can worsen symptoms Your dermatologist may adjust treatment based on the severity and frequency of your flare-ups

Indeed, MDA levels could precisely indicate the severity of lipid peroxidation injury, one of the initiating links of endothelial dysfunction in atherosclerosis (53)

It also helps with discoloration and dark patches