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DAMPs usually activate the innate immune response and macrophages are recruited and activated to secrete various mediators such as macrophage inhibitory protein-1, monocyte chemoattractant protein-1, and IL-8, leading to interstitial inflammation in the kidney [108]

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The reactions that matter more are the allergic ones, covered next

Monitoring: As with any IV push, administration by or under the supervision of a trained clinician with appropriate monitoring is recommended

In yeast, PUS7p deficiency has been shown to reduce the stability of -containing transcripts during heat shock [100]