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NAD+ supports mitochondrial energy production and activates DNA-repair enzymes and sirtuins, while glutathione defends cells against the oxidative stress that can accelerate aging

Mechanistic studies to better understand the molecular targets and pathways involved in peptide action could help identify potential adverse effects and inform safer clinical use

Calisto and Esteves 2009)

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We believe that it is reasonable to require an enhanced disclosure to the patient who may be prescribed one of these drugs that this molecule is not as well-characterized as drugs that would normally be dispensed to patients, and the patient needs to understand that there may be a higher risk profile, and they should only be taken under the care of a physician, he said