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J Clin Oncol 2022 ASCO Annual Meeting 40(suppl), 2022
22 Interestingly, UV levels have also been shown to influence activity of the cSHMT enzyme, with a preliminary study observing translation of this enzyme as increased significantly in UV-exposed cells
In addition, when GSH is depleted, monocyte-derived macrophages significantly increase their production of reactive oxygen species (ROS), further amplifying oxidative damage within the CNS ( Overall, GSH helps limit unwanted immune attacks in the brain
During the first half of the 20th century, clinical observations and anatomical and biochemical studies formed the basis of the understanding of the structure of GH and its various metabolic effects in animals
