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Two estimands were employed: the trial product estimand, which evaluated treatment effects assuming perfect adherence to the assigned regimen, and the treatment policy estimand, which included all randomized participants regardless of adherence

Injectable pyridoxine is usually administered IM or IV, though some formularies include SubQ as a possible route

The time it takes for B12 treatment to work depends on several factors, including the severity of deficiency, the route of administration, and individual patient characteristics

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Early detection makes treatment much more effective