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Typical daily intake targets are about 600 IU per day for most adults, and 800 IU per day after age 70

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The mechanisms sustaining this heterogeneity are unknown, although it should be acknowledged that CVOTs lack the statistical power to reliably detect differences in specific MACE components

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By enhancing levels of dopamine, norepinephrine, and serotonin, tesofensine appears to suppress appetite and elevate mood, which may help mitigate some of the underlying drivers of stimulant misuse