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Mechanistically, IGFBP-2 can activate STAT3 to increase the transcriptional activity of C-X-C motif ligand 1 (CXCL1), thereby increasing the intracellular expression level of CXCL1, which contributes to the survival of lung cancer cells in the gefitinib environment (136)

Torres-Arce E, Vizmanos B, Babio N, Mrquez-Sandoval F, Salas-Huetos A

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[DOI] [PMC free article] [PubMed] [Google Scholar] 8.Randolph M., Tosti A

Cell Culture Applications Cell Sciences Technical Literature The widespread use of Long-R3-IGF-I as a recombinant cell-culture supplement is documented in technical and methods literature published by manufacturers and end users in pharmaceutical bioprocessing, stem-cell maintenance, and other in vitro applications