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Dose escalation study of crenolanib in combination with high dose cytarabine/idarubicin salvage chemotherapy in multiply relapsed FLT3 positive AML

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Gastroenterology 158, 1999

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Genetic variations in enzymes of the leukotriene synthetic pathway may cause some individuals with asthma to produce cysteinyl-leukotrienes (cys-LTs) to a greater extent than other patients, predisposing them to more severe asthma symptoms (particularly poorer lung function), and perhaps defining those individuals who may show the best clinical responses to LTRA therapy

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