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Delta sleep inducing peptide inhibits somatostatin release via a dopaminergic mechanism

February 2026

Lipid peroxidation generates hydroperoxides as well as endoperoxides, which undergo fragmentation to produce a broad range of reactive intermediates called reactive carbonyl species (RCS) such as isoprostanes (IsoPs), neuroprotanes, malondialdehyde, unsaturated aldehydes including 4-hydroxy-2- trans -nonenal (HNE), 4-hydroxy-2- trans -hexenal (HHE), and 2-propenal (acrolein), with different degrees of reactivity (Porter et al., Clearly, the concurrency of these factors in the presence of high amounts of polyunsaturated fatty acids, mainly DHA, is expected to favor the free radical-induced peroxidation of DHA in the brain parenchyma (Van Kuijk et al., Nerve cells are endowed with different antioxidant systems that render them protected from oxidative damage caused by lipid peroxides

To maintain healthy body fat composition, which in turn supports insulin sensitivity and healthy blood sugar levels already within normal range