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3.3.3 GPX4-independent ferroptosis pathways In addition to GPX4-dependent antioxidant system in ferroptosis, so far there are alternative identified ferroptosis pathways, including ferroptosis suppressor protein 1(FSP1)/coenzyme Q10 (Co Q10) (Mao et al., 2021), GTP cyclohydrolase 1 (GCH1)/ tetrahydrobiopterin (BH4) (Kraft et al., 2020), 7-dehydrocholesterol (7-DHC) (Cao et al., 2025), and phospholipid modifying enzymes MBOAT1/2 (Li et al., 2023)
In addition, fermentation increases glutathione, an anti aging amino acid, and enzymes needed for digestion and detoxification. And dont forget all the fiber
One study with 34 participants with metastatic uveal melanoma showed positive outcomes, with an overall survival of 14.4 months
A phase I study of autologous mesenchymal stromal cells for severe steroid-dependent nephrotic syndrome
In mice it blunted alcohol intoxication and prevented deadly withdrawal, and it seems to act through the gut-brain axis
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