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However, this process is non-selective and influenced by regional differences in receptor density, blood flow, and hormonal sensitivity

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[DOI] [PubMed] [Google Scholar] [157].Sturniolo GC, Fries W, Mazzon E, Di Leo V, Barollo M, DInca R

In some embodiments, the pH of the formulations or compositions described herein is adjusted (e.g., by use of a buffer) to a perilymphcompatible pH of about 7.0-7.6, and a preferred pH range of about 7.2-7.4