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[2] Some individuals do experience gastrointestinal side effects when taking B12 supplements, particularly when first beginning supplementation

Age-Related Deficiency Factors Getting older increases the risk of vitamin B12 deficiency

Kalamakis G et al (2019) Quiescence modulates stem cell maintenance and regenerative capacity in the aging brain

This regulatory status establishes these peptides strictly as research-use-only materials appropriate exclusively for laboratory investigation in qualified research settings rather than any form of clinical, therapeutic, or diagnostic application

This is uncommon, but it is a reason to address a deficiency before it progresses