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Through the interaction of TNF and its receptors, key signaling pathways can be activated, such as the NF-B pathway, RANKL signaling, the extracellular signal-regulated kinase (ERK) signaling pathway, the tumor progression locus 2 (TPL2) pathway, and proapoptotic signaling

Raghunath, S., Glikmann-Johnston, Y., Hanly, J

Unal et al., 2018), and shaping response selectivity of cortical neurons (Vidyasagar et al., 1996

doi: 10.1161/01.RES.69.4.1088

When young patients exhibit symptoms, such as deep or superficial sensory disturbances, motor dysfunction, cognitive deficits, or psychiatric issues, further investigation is warranted