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This route expanded after the April 2026 reclassification opened the injectable pathway

AES16-2M wound healing peptide Researchers at Korea University identified the peptide AES16-2M (amino acid sequence REGRT) as a candidate for atopic dermatitis treatment

Despite promising preclinical data, clinical trials in humans are extremely limited, and the compound remains largely experimental, with ongoing research required to fully characterize pharmacokinetics, optimal dosing, long-term safety, and potential off-target effects.

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In the absence of prohibitive surgical risk factors, all symptomatic patients should undergo elective laparoscopic repair to prevent severe complications, and even mortality, which can occur should an urgent surgical procedure become necessary