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475 Overall, 32% of Medicare beneficiaries living with Alzheimer's or other dementias have at least one hospital discharge annually compared with 15% of beneficiaries without these conditions, with average hospital stays of 5.1 days versus 4.5 days, respectively

Schiavone S, Colaianna M, Curtis L (2015) Impact of early life stress on the pathogenesis of mental disorders: relation to brain oxidative stress

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R 4-OH catechol estrogens that are not methylated by COMT can be oxidized to quinones that generate reactive oxygen species and form DNA adducts, a mechanism implicated in estrogen-dependent cancers