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NAPQI-GST Formation by CYP3A4 CYP3A4 Supersomes (1 mg/mL protein, 125 pmol/mL CYP3A4 final concentration) and APAP (100 M) were incubated (37C and 500 rpm) in the presence of NADPH (1 mM in phosphate buffer)

doi: 10.3390/reprodmed1010004 2

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These studies are mechanistically aligned with the VEGFR2/eNOS in vitro findings but rely on the same originating laboratory and rodent model system, and independent replication outside that network is sparse

therefore, the anti-inflammatory effects of L-carnitine in fish require further study