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Additionally, ROS can also trigger other cell death events in lens epithelial cells, such as apoptosis characterized by upregulation of the pro-apoptotic Bcl-2-associated X protein ( BAX ) gene and downregulation of the anti-apoptotic B-cell lymphoma-2 ( BCL-2 ) gene [30] as well as pyroptosis mediated by ROS-induced activation of the NLRP3 inflammasome/caspase 1/gasdermin D pathway [31]

Also known as ascorbic acid

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A few medications have been repurposed to address metabolic disturbances, such as the insulin sensitiser metformin, widely used for the treatment of PCOS since the 1990s

Transferrin and transferrin receptors update