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The ferroptosis pathway involves several critical mechanisms: iron uptake via transferrin receptor, ferritinophagy mediated by nuclear receptor coactivator 4 (NCOA4), iron export through ferroportin regulated by hepcidin, accumulation of lipid peroxides via the Fenton reaction, and antioxidant defense via glutathione peroxidase 4 (GPx4) and glutathione (GSH)

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demonstrated that curcumin suppresses aldosterone-induced C-reactive protein (CRP) production in vascular smooth muscle cells by inhibiting the ROS-ERK1/2 signaling pathway (Zhang et al., 2020a)

"The intersection between cell wall disassembly, ripening, and fruit susceptibility to Botrytis cinerea"

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