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Functionally, iEV-150 reprograms tumor metabolism by activating YAP signaling, upregulating ferroptosis-related genes, and inducing lipid peroxidation, while simultaneously modulating the immune microenvironment to enhance checkpoint blockade efficacy [206]

Carcinogenicity of dietary aflatoxin M1 in male Fischer rats compared to aflatoxin B1

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One of the formed products after converting AA by the 5-LO/FLAP complex is leukotriene A4 (LTA4) which is converted by leukotriene C4 synthase (LTC4S) to leukotriene C4 (LTC4)

Goodwin et al, 2009