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Cells were washed once with PBS and treated with 5 g ml 1 ciprofloxacin (MP Biomedicals) in the presence of 1080 M KL1 or 0.2% DMSO for 24 h

Serine and glycine also charge the folate pool with one-carbon units, including N 10 -formyl-THF, that are ultimately used to produce nucleotides, methionine, and S-adenosylmethionine, the latter of which is the major methyl donor for methyltransferase reactions including those of DNA and histones [62, 63]

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These include nausea, dizziness, muscle cramping, diarrhoea, dehydration, weight gain, bloating, heat intolerance, and gastrointestinal pain [8, 4, 9, 10]