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Comprehensive safety studies spanning six months in rats (up to 100 mg/kg/day) and nine months in cynomolgus monkeys (up to 50 mg/kg/day) revealed no adverse findings, with NOAEL reaching the highest applied dosages

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Mitomycin C also leads to cardiac damage, and the prevalence of heart failure increases when used along with anthracyclines

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Not only is the hormone imbalance physically stressful, it is also associated with several other related mental/life imbalances

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"DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status"

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