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The low-fat fish oil intervention demonstrated promising secondary outcomes compared with the Western diet group, including favorable shifts in prostate tissue fatty acid composition (reduced omega-6:omega-3 ratios), decreased cellular proliferation (as measured by Ki-67 index), and inhibited cancer cell growth in ex vivo experiments using patient sera

These effects of vitamin D3, as well as a resulting increase in GSH levels, have been functionally documented in cell culture studies (28, 29) and in human subjects (30)