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The same gene defect can cause a severe and rapidly fatal childhood leukodystrophy or a more indolent adult-onset myelopathy and neuropathy

The mechanism of allopurinol in optimizing thiopurine therapy is complex and may lie in the ability of allopurinol to inhibit XDH and saturate or limit the methylating capacity of TPMT ( Figure 1 )

Efficacy of cipargamin (KAE609) in a randomized, phase II dose-escalation study in adults in sub-Saharan Africa with uncomplicated Plasmodium falciparum malaria

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