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Novel biologics are being designed with the help of synthetic fusion proteins, monoclonal antibodies, and protein fragments, with or without drugs, to target various signaling pathways, including TNF-, IL-6, JAK, Th-17, IL-family, GM-CSF, B-cell, and T-cell signaling

5) Gaps in understanding ferroptosis in DN comorbidities: DN patients often present with comorbidities (e.g., hypertension, obesity, and dyslipidemia) that exacerbate renal injury, but how these comorbidities interact with ferroptosis in DN is unexplored

an unusual or allergic reaction to methylcobalamin, cobalt, other medicines, foods, dyes, or preservatives

Comparisons like BAC water versus sterile water clarify proper application choices

Similarly, an overdose of VD may also cause adverse health effects [155]