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This is the mechanism that makes TB-500 relevant to injuries that involve slow or stalled healing: when the local repair response has exhausted its resources, TB-500 recruits fresh cells from the surrounding tissue and circulatory system into the damage zone
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Of note, intra-abdominal hypertension is quite frequent in critically ill patients and the cause of multiorgan dysfunction (Schachtrupp et al., 2007) (here, 25, 30, 40, and 50 mm Hg by intraperitoneal insufflation of ordinary air controlled and maintained by a manual manometer leads to invariable abdominal compartment syndrome), correlate fairly well with the circumstances in humans
Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor
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