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High concentrations of IGF-I were associated with an increased risk of prostate cancer (odds ratio comparing 75th with 25th percentile 149, 95% CI 114195) and premenopausal breast cancer (165, 126208) and high concentrations of IGFBP-3 were associated with increased risk of pre-menopausal breast cancer (151, 101227)

The drive for lighter skin, influenced by societal and cultural factors, can negatively impact individuals' psychological well-being

It helps to reduce oxidative stress and inflammation, which are key factors in the development of heart disease