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Additionally, neurotrophic factors such as IGF-1 and BDNF are critical targets for facilitating slower rates of structural and functional decline in the brain with advancing ageas both promote neurogenesis (Park and Poo, 2013

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This makes it a valuable tool for assessing the mechanisms underlying -cell dysfunction in this condition

Consider supplementation when the patient has risk factors associated with B 12 Deficiency as described in see Table 1: Patient Risk Factors Associated with B 12 Deficiency above