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Blood pressure medications - DSIP may have mild cardiovascular effects

Cagrilintide is a standalone long-acting amylin analog targeting amylin receptors (calcitonin receptor + RAMPs)

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Subsequent chemical modifications, which were designed to increase hydrophobicity and decrease hydrogen bonding, yielded an orally active, blood-barrier permeant, metabolically stabilized analog, N -hexanoic-Tyr-Ile-(6) aminohexanoic amide (dihexa), that exhibits excellent antidementia activity in the scopolamine and aged rat models and marked synaptogenic activity

In vivo recordings : chronic electrodes in CA1 to measure theta/gamma oscillations, sharp-wave-ripples (mnemonic replay)