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Molecules 15:10411073

Clock genes such as Rev-erb repress distal enhancers resulting in the repression of macrophages (Lam et al., 2013), whereas Bmal1 which controls rhythmic trafficking of inflammatory monocytes to sites of inflammation (Nguyen et al., 2013)

In dietinduced obese mice, NNMTi treatment significantly reduced liver weight, liver volume, and hepatic triglyceride levels, alleviated hepatic steatosis and inflammatory infiltration, downregulated inflammatory factors (such as TNF and IL6) and lipogenic genes (such as FAS), and upregulated lipolytic genes (such as ATGL) in the liver

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That dual approach to energy balance is what researchers believe drives the superior weight loss outcomes