After 24 weeks, there were significantly greater improvements in the NAC group in PANSS total, negative, and general qualitative measures (p = 0.009, 0.018, and 0.035, respectively) and CGI- Severity (CGI-S) and CGI-Improvement (CGI-I) scores (p = 0.004, and 0.025, respectively) [146]
Neurological Protection and Brain Health The brain is particularly vulnerable to oxidative stress due to its high oxygen consumption, abundant polyunsaturated fatty acids susceptible to lipid peroxidation, and relatively modest intrinsic antioxidant defences
P values 0.05 were considered statistically significant
In vascular smooth muscle cells (VSMCs), it disrupts the TCA cycle and provokes ROS production, leading to cellular hypertrophy and phenotypic switching, which culminates in pathological thickening of the vascular wall [102]
It achieves this by enhancing collateral pathways, which compensates for the occlusion of major vessels, thereby preventing glaucomatous damage
