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It lies between the blood and the vessel wall, is synthesized and secreted by vascular endothelial cells, and is a dynamic natural barrier that is principally composed of proteoglycans, membrane glycoproteins, and plasma proteins, of which proteoglycans and glycoproteins are the main components (16)

No differences in 5-HT2A receptors in mid-life depression or LLD, lower 5HT2A receptors in mid-life depression in orbital-frontal cortex, and higher 5-HT2A receptors have been reported [109,110,111,112]

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