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This endogenous activation provides sustained cellular protection compared to direct free radical scavenging by exogenous antioxidants

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10.1016/j.brainres.2017.04.019 189 HorsagerJ.AndersenK

Some are FDA-approved medications (like GLP-1 receptor agonists), while others are research compounds

This was a 15-year-old boy who presented with mental retardation, mild motor impairment, and partial deafness