Vitamin B12 deficiency can also cause symptoms that affect the brain and nervous system (neurologic symptoms), including: Numbness Muscle weakness Mental health problems, ranging from mild depression or anxiety to confusion and dementia Balance and coordination issues Needles and pins Incontinence What is the best form of vitamin B12 to take
Adverse Reactions/Side Effects The following serious adverse reactions are described below or elsewhere in the prescribing information: Risk of Thyroid C-cell Tumors [see Warnings and Precautions (5.1)] Acute Pancreatitis [see Warnings and Precautions (5.2)] Hypoglycemia with Concomitant Use of Insulin Secretagogues or Insulin [see Warnings and Precautions (5.3)] Hypersensitivity Reactions [see Warnings and Precautions (5.4)] Acute Kidney Injury Due to Volume Depletion [see Warnings and Precautions (5.5)] Severe Gastrointestinal Adverse Reactions [see Warnings and Precautions (5.6)] Diabetic Retinopathy Complications in Patients with a History of Diabetic Retinopathy [see Warnings and Precautions (5.7)] Acute Gallbladder Disease [see Warnings and Precautions (5.8)] Pulmonary Aspiration During General Anesthesia or Deep Sedation [see Warnings and Precautions (5.9)] 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice
Where results are borderline, measurement of methylmalonic acid (MMA) or holotranscobalamin (active B12) may help clarify the picture, as recommended in NICE CKS guidance on B12 and folate deficiency anaemia
Your Plan Should Be Too
(PubMed) Zuin M, Cervellati C, Brombo G, Trentini A, Roncon L, Zuliani G
