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In a neuronal-like rat pheochromocytoma cell model stimulated by cadmium oxide, L-theanine could reduce the synthesis of reactive oxygen species (ROS) and enhance the activity of antioxidant enzymes to weaken oxidative damage ( Escherichia coli (ETEC)-infected mice ( Generally, L-theanine has strong antioxidant activity, which can be associated with the regulation of the expression and activities of antioxidant-related enzymes

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In addition, innate-driven cell death modalities such as ferroptosis or cuproptosis may sustain depigmentation in the absence of robust T cell activity, potentially accounting for treatment resistance or disease relapse