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Thus, GSH supplementation in the DG sub-group of elderly diabetic patients over a period of 6 months led to a significant increase in the erythrocyte GSH, GSSG, and FPI and a decrease in HbA1c and 8-OHdG levels (Figure S2), suggesting that the elderly diabetic population responds better to GSH supplementation in conjunction with anti-diabetic therapy

Collectively, these data indicated that VRK2 had a positive effect on ER-to-Golgi trafficking of SLC7A11, while VRK2 deficiency impede the transport of SLC7A11

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