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Similarly, the MetaCell system demonstrated the ability to evade immune detection, penetrate breast tumor cells, and promote both cuproptosis and ferroptosis, which resulted in significant anti-tumor effects in vitro and in vivo ( 5.3 Clinical trials targeting ferroptosis and cuproptosis in breast cancer Recent clinical trials are investigating ferroptosis and cuproptosis modulation as promising strategies for treating breast cancer, particularly in advanced or treatment-resistant cases (ClinicalTrials.gov)

Notably, excessive ROS can further exacerbate calcium homeostasis disorders by damaging the sarcoplasmic reticulum Ca-ATPase and mitochondrial calcium uniporter, forming a malignant cascade of excessive ROS-calcium imbalance-energy crisis [136]

Some researchers found that those with high B12 levels have shorter lifespans

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The suppressing effects of Dkk3 expression on aggressiveness and tumorigenesis of colorectal cancer