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Concurrently, TMAO suppresses BAs synthesis, disrupts cholesterol metabolism, aggravates intrahepatic lipid accumulation, promotes foam cell formation, and inhibits reverse cholesterol transport (RCT), thereby further compromising hepatic lipid homeostasis (Janeiro et al., 2018)
Lifestyle intervention Several major trials have shown some effective interventions to prevent the occurrence of T2D and even reduce the risk of TOD
This is because the liver is responsible for filtering toxins and metabolic byproducts from the blood
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Additionally, Minuk and Lewkonia (1986) have even reported familial clustering of Inflammatory Bowel Disease (IBD) and MS, suggesting that they have genetic or environmental risk factors in common
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