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10.1007/978-3-642-00663-0_7 Adverse Drug Reactions

[7] Research has indicated a potential area of interest for DSIP in the study of withdrawal symptoms from opiate and alcohol addictions, which has been supported by the results of studies in animals conducted by Tissot and the fact, that DSIP possesses an agonistic activity on opiate receptors

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This uncoupling process reduces the efficiency of oxidative phosphorylation, resulting in increased substrate oxidation and energy expenditure, with excess energy released as heat