When there is excessive accumulation of LIP in chondrocytes, the overloaded Fe 2+ catalyzes the explosive generation of ROS through the iron-dependent Fenton reaction (Yang et al., 2024)
Transcriptomic studies have characterized the compound as influencing the expression of a large number of genes, published analyses have reported effects on the expression of more than four thousand human genes, across the directional categories studied, with notable enrichment in pathways related to extracellular matrix remodeling, cellular proliferation, antioxidant response, and copper homeostasis
Assavarittirong C, Samborski W, Grygiel-Grniak B
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Bioresour Technol 199:103112 Jnsson LJ, Alriksson B, Nilvebrant N-O (2013) Bioconversion of lignocellulose: inhibitors and detoxification