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Expression of Cyp8b1, the sterol 12-hydroxylase required for generation of CA, was decreased in Insr P1195L/ +/HFD mice (Fig

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C1q/TNF-related protein 5 upregulates 12/15-LOX through STAT6 signaling to accelerate the development of atherosclerosis, while inhibition of 12/15-LOX reduces LDL oxidation and improves atherosclerosis

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