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Developing targeted therapies that leverage NOs complex roles will require a more comprehensive understanding of the delicate balance between its tumor-promoting and tumor-suppressing activities

Modification of the ethyl chain and the introduction of a benzylic moiety on the aromatic amine produced derivatives such as SRS11-92 (EC50 = 6 nM), which demonstrated significantly enhanced potency

Glutathione IV therapy is generally safe and well tolerated

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