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B 0 is the baseline motor score, E max is the maximum inhibitory effect, Cp is the apomorphine plasma concentration predicted by the PK model, Ce is the drug concentration at the site of action, EC 50 is the drug concentration that causes 50% of the maximum effect, g is the Hills sigmoid coefficient, and k e0 is the first-order plasma-effect-site equilibration rate constant

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When evaluating side effects, the following frequencies are used as a basis: Very common: more than 1 in 10 people Common: less than 1 in 10, but more than 1 in 100 patients Uncommon: less than 1 in 100, but more than 1 in 1000 patients Rare: less than 1 in 1,000 but more than 1 in 10,000 patients Very rare: less than 1 in 10,000 patients treated, or unknown