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& Rehm, B
This testing period covers the most vulnerable phase of embryonic development when cancer-causing substances would be most likely to produce abnormalities
Observed side effects in research environments are generally mild and temporary, most commonly including: Temporary fatigue-related observations Mild fluid-retention variability Increased hunger- or appetite-related observations Mild headache-related observations Minor administration-site irritation such as redness or temporary administration-site sensitivity observations Proper reconstitution, sterile handling practices, proper administration techniques, and regular administration-site rotation are important for minimizing local irritation and maintaining peptide stability and consistency during research use
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Phase 2 dose-ranging trials followed in 20042006, and the pivotal Phase 3 trials (studies LIPO-010-05 and LIPO-010-06) ran from 2006 to 2009 , forming the efficacy basis for the November 2010 FDA approval
